1w70

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spinqualitylabelsall models 1w70, resolution 1.46Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

SH3 DOMAIN OF P40PHOX COMPLEXED WITH C-TERMINAL POLYPROLINE REGION OF P47PHOX

Overview

The neutrophil NADPH oxidase produces superoxide anions in response to, infection. This reaction is activated by association of cytosolic factors, p47phox and p67phox, and a small G protein Rac with the membranous, flavocytochrome b558. Another cytosolic factor, p40phox, is associated to, the complex and is reported to play regulatory roles. Initiation of the, NADPH oxidase activation cascade has been reported as consecutive to, phosphorylation on serines 359/370 and 379 of the p47phox C terminus., These serines surround a polyproline motif that can interact with the Src, homology 3 (SH3) module of p40phox (SH3p40) or the C-terminal SH3 of, p67phox (C-SH3p67). The latter one presents a higher affinity in the, resting state for p47phox. A change in SH3 binding preference following, ... [(full description)]

About this Structure

1W70 is a [Protein complex] structure of sequences from [Homo sapiens] with SO4, ACE and TFA as [ligands]. Full crystallographic information is available from [OCA].

Reference

Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains., Massenet C, Chenavas S, Cohen-Addad C, Dagher MC, Brandolin G, Pebay-Peyroula E, Fieschi F, J Biol Chem. 2005 Apr 8;280(14):13752-61. Epub 2005 Jan 18. PMID:15657040

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