1qz7

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Image:1qz7.png

Template:STRUCTURE 1qz7

Contents

Beta-catenin binding domain of Axin in complex with beta-catenin

Template:ABSTRACT PUBMED 14600025

Disease

Known disease associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]

About this Structure

1QZ7 is a 2 chains structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Xing Y, Clements WK, Kimelman D, Xu W. Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev. 2003 Nov 15;17(22):2753-64. Epub 2003 Nov 4. PMID:14600025 doi:10.1101/gad.1142603

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