2phb

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Image:2phb.png

Template:STRUCTURE 2phb

Contents

An Orally Efficacious Factor Xa Inhibitor

Template:ABSTRACT PUBMED 17683371

Disease

Known disease associated with this structure: Factor X deficiency OMIM:[227600]

About this Structure

2PHB is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarb oxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem Biol Drug Des. 2007 Aug;70(2):100-12. PMID:17683371 doi:10.1111/j.1747-0285.2007.00539.x

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