2aq7

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Image:2aq7.png

Template:STRUCTURE 2aq7

Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

Template:ABSTRACT PUBMED 16392800

About this Structure

2AQ7 is a 4 chains structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem. 2006 Jan 12;49(1):159-71. PMID:16392800 doi:http://dx.doi.org/10.1021/jm050825p

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