2dx5

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Image:2dx5.gif

2dx5, resolution 3.35Å

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The complex structure between the mouse EAP45-GLUE domain and ubiquitin

Overview

ESCRT-II, a complex that sorts ubiquitinated membrane proteins to, lysosomes, localizes to endosomes through interaction between the Vps36, subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a, ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas, its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45, GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site, of Eap45 GLUE, suggesting their independent binding.

About this Structure

2DX5 is a Protein complex structure of sequences from Bos taurus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain., Hirano S, Suzuki N, Slagsvold T, Kawasaki M, Trambaiolo D, Kato R, Stenmark H, Wakatsuki S, Nat Struct Mol Biol. 2006 Nov;13(11):1031-2. Epub 2006 Oct 22. PMID:17057714

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