2iko

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spinqualitylabelsall models PDB ID 2iko Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2iko, resolution 1.90Å ()
Ligands:
Gene:	REN (Homo sapiens)
Activity:	Renin, with EC number 3.4.23.15
Structural annotation: Resources: InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797
Functional annotation: Cellular component: extracellular space membrane Biological process: regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation Molecular function: hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal Structure of Human Renin Complexed with Inhibitor 2 Disease 3 About this Structure 4 Reference

Crystal Structure of Human Renin Complexed with Inhibitor

Template:ABSTRACT PUBMED 17113558

Disease

Known disease associated with this structure: Renal tubular dysgenesis OMIM:[179820], Hyperproreninemia OMIM:[179820]

About this Structure

2IKO is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:17113558 doi:http://dx.doi.org/10.1016/j.ab.2006.10.017

Page seeded by OCA on Tue Feb 17 15:54:58 2009