2o8m

From Proteopedia

Revision as of 14:22, 17 February 2009 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2o8m.png

Template:STRUCTURE 2o8m

Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease

Template:ABSTRACT PUBMED 17444623

About this Structure

2O8M is a 4 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623 doi:10.1021/jm060173k

Page seeded by OCA on Tue Feb 17 16:22:03 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o8m"
Personal tools