2an3

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Image:2an3.png

Template:STRUCTURE 2an3

Contents

Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol.

Template:ABSTRACT PUBMED 16363801

Disease

Known disease associated with this structure: Hypertension, essential, 145500 (1) OMIM:[171190]

About this Structure

2AN3 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis. Biochemistry. 2005 Dec 27;44(51):16875-85. PMID:16363801 doi:http://dx.doi.org/10.1021/bi051636b

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