2bt4

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Image:2bt4.gif

2bt4, resolution 1.70Å

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TYPE II DEHYDROQUINASE INHIBITOR COMPLEX

Overview

Selective inhibitors of type II dehydroquinase were rationally designed to, explore a second binding-pocket in the active-site. The molecular, modelling, synthesis, inhibition studies and crystal structure, determination are described.

About this Structure

2BT4 is a [Single protein] structure of sequence from [Streptomyces coelicolor] with PO4, CA2, TRS and GOL as [ligands]. Active as [[1]], with EC number [4.2.1.10]. Full crystallographic information is available from [OCA].

Reference

Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291

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