2fkl

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spinqualitylabelsall models PDB ID 2fkl Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2fkl, resolution 2.50Å ()
Gene:	APP (Homo sapiens)
Related:	1owt, 2fjz, 2fk1, 2fk2, 2fk3
Structural annotation: Resources: InterPro : Ipr008154, Ipr013803, Ipr015849, Ipr011178, Ipr002223, Ipr008155 Pfam : PF02177 UniProt : P05067
Functional annotation: Cellular component: coated pit extracellular region integral to plasma membrane integral to membrane membrane cell surface Biological process: cell adhesion neuromuscular process apoptosis cellular copper ion homeostasis endocytosis Notch signaling pathway Molecular function: endopeptidase inhibitor activity identical protein binding binding protein binding serine-type endopeptidase inhibitor activity zinc ion binding heparin binding metal ion binding iron ion binding copper ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP) 2 Disease 3 About this Structure 4 Reference

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)

Template:ABSTRACT PUBMED 17239395

Disease

Known disease associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760]

About this Structure

2FKL is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW. Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol. 2007 Mar 16;367(1):148-61. Epub 2006 Dec 21. PMID:17239395 doi:10.1016/j.jmb.2006.12.041

Page seeded by OCA on Tue Feb 17 18:34:43 2009