1u0n

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Image:1u0n.png

Template:STRUCTURE 1u0n

Contents

The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex

Template:ABSTRACT PUBMED 15665869

Disease

Known disease associated with this structure: Bernard-Soulier syndrome, benign autosomal dominant OMIM:[606672], Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672]

About this Structure

1U0N is a 4 chains structure of sequences from Bothrops jararaca and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fukuda K, Doggett T, Laurenzi IJ, Liddington RC, Diacovo TG. The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation. Nat Struct Mol Biol. 2005 Feb;12(2):152-9. Epub 2005 Jan 16. PMID:15665869 doi:10.1038/nsmb892

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