1h9d

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Template:STRUCTURE 1h9d

Contents

AML1/CBF-BETA/DNA COMPLEX

Template:ABSTRACT PUBMED 11276260

Disease

Known disease associated with this structure: Leukemia, acute myeloid OMIM:[151385], Platelet disorder, familial, with associated myeloid malignancy OMIM:[151385], Rheumatoid arthritis, susceptibility to OMIM:[151385], Myeloid leukemia, acute, M4Eo subtype OMIM:[121360]

About this Structure

1H9D is a 8 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:http://dx.doi.org/10.1038/86264

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