2bpm

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Image:2bpm.png

Template:STRUCTURE 2bpm

STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529

Template:ABSTRACT PUBMED 15828833

About this Structure

2BPM is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pevarello P, Brasca MG, Orsini P, Traquandi G, Longo A, Nesi M, Orzi F, Piutti C, Sansonna P, Varasi M, Cameron A, Vulpetti A, Roletto F, Alzani R, Ciomei M, Albanese C, Pastori W, Marsiglio A, Pesenti E, Fiorentini F, Bischoff JR, Mercurio C. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization. J Med Chem. 2005 Apr 21;48(8):2944-56. PMID:15828833 doi:10.1021/jm0408870

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