2i1m

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Image:2i1m.png

Template:STRUCTURE 2i1m

Contents

cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor

Template:ABSTRACT PUBMED 17132624

Disease

Known disease associated with this structure: Myeloid malignancy, predisposition to OMIM:[164770]

About this Structure

2I1M is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA. Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors. J Biol Chem. 2007 Feb 9;282(6):4094-101. Epub 2006 Nov 28. PMID:17132624 doi:http://dx.doi.org/10.1074/jbc.M608183200

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