2g7h
From Proteopedia
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Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)
Overview
The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the, thermophile Methanococcus jannaschii has been determined using, multinuclear multidimensional NMR spectroscopy. The structure is similar, to homologs from other organisms that have been determined by, crystallography, with some variation in the N-terminal domain. The, C-terminal domain is more highly conserved in both sequence and structure., Regions of the protein show broadening, reflecting conformational, flexibility that is likely related to function.
About this Structure
2G7H is a Single protein structure of sequence from Methanocaldococcus jannaschii. Active as [protein-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number 2.1.1.63 Full crystallographic information is available from OCA.
Reference
Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase., Roberts A, Pelton JG, Wemmer DE, Magn Reson Chem. 2006 Jul;44 Spec No:S71-82. PMID:16826543[[Category: Methylated-DNA--[protein]-cysteine S-methyltransferase]]
Page seeded by OCA on Wed Nov 21 11:00:37 2007
