1umx

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spinqualitylabelsall models 1umx, resolution 2.8Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ARG M267 REPLACED WITH LEU (CHAIN M, R267L)

Overview

Relatively little is known about the functions of specific molecular, interactions between membrane proteins and membrane lipids. The structural, and functional consequences of disrupting a previously identified, interaction between a molecule of the diacidic lipid cardiolipin and the, purple bacterial reaction centre were examined. Mutagenesis of a highly, conserved arginine (M267) that is responsible for binding the head-group, of the cardiolipin (to leucine) did not affect the rate of photosynthetic, growth, the functional properties of the reaction centre, or the X-ray, crystal structure of the complex (determined to a resolution of 2.8 A)., However, the thermal stability of the protein was compromised by this, mutation, part of the reaction centre population showing an approximately, ... [(full description)]

About this Structure

1UMX is a [Protein complex] structure of sequences from [Rhodobacter sphaeroides] with FE, PO4, LDA, BCL, BPB, SPN and U10 as [ligands]. Full crystallographic information is available from [OCA].

Reference

Disruption of a specific molecular interaction with a bound lipid affects the thermal stability of the purple bacterial reaction centre., Fyfe PK, Isaacs NW, Cogdell RJ, Jones MR, Biochim Biophys Acta. 2004 Jan 30;1608(1):11-22. PMID:14741581

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