2ec8

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Template:STRUCTURE 2ec8

Contents 1 Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit 2 Disease 3 About this Structure 4 Reference

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

Template:ABSTRACT PUBMED 17662946

Disease

Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[164920], Germ cell tumors OMIM:[164920], Leukemia, acute myeloid OMIM:[164920], Mast cell leukemia OMIM:[164920], Mastocytosis with associated hematologic disorder OMIM:[164920], Piebaldism OMIM:[164920]

About this Structure

2EC8 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell. 2007 Jul 27;130(2):323-34. PMID:17662946 doi:http://dx.doi.org/10.1016/j.cell.2007.05.055

Page seeded by OCA on Wed Feb 18 04:06:19 2009