3bv9

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Image:3bv9.png

Template:STRUCTURE 3bv9

Contents

Structure of Thrombin Bound to the Inhibitor FM19

Template:ABSTRACT PUBMED 18315550

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3BV9 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nieman MT, Burke F, Warnock M, Zhou Y, Sweigart J, Chen A, Ricketts D, Lucchesi BR, Chen Z, Di Cera E, Hilfinger J, Kim JS, Mosberg HI, Schmaier AH. Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo. J Thromb Haemost. 2008 May;6(5):837-45. Epub 2008 Feb 25. PMID:18315550 doi:10.1111/j.1538-7836.2008.02937.x
  • Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200

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