2h67

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Image:2h67.png

Template:STRUCTURE 2h67

Contents

NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures

Template:ABSTRACT PUBMED 16728398

Disease

Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

2H67 is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Hua QX, Liu M, Hu SQ, Jia W, Arvan P, Weiss MA. A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog. J Biol Chem. 2006 Aug 25;281(34):24889-99. Epub 2006 May 25. PMID:16728398 doi:10.1074/jbc.M602617200

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