2hmh
From Proteopedia
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Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.
Overview
Suppressor of cytokine signaling (SOCS) proteins are indispensable, negative regulators of cytokine-stimulated Janus kinase (JAK)-signal, transducer and activator of transcription (STAT) signaling pathways. SOCS, proteins (SOCS1-7 and CIS) consist of a variable N-terminal region, a, central Src homology-2 (SH2) domain, and a C-terminal SOCS box. The, N-terminal region in SOCS1 and SOCS3 includes the so-called kinase, inhibitory region that has been shown to inhibit the catalytic activity of, JAK2. Here, we present a crystal structure at 2.0 A resolution of the, N-terminally extended SH2 domain of SOCS3 in complex with its, phosphopeptide target on the cytokine receptor gp130. The structure, reveals that major insertions in the EF and BG loops of the SOCS3 SH2, domain are responsible for binding to gp130 with high affinity and, specificity. In addition, the structure provides insights into the, possible mechanisms by which SOCS3 and SOCS1 inhibit JAK2 kinase activity.
About this Structure
2HMH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3., Bergamin E, Wu J, Hubbard SR, Structure. 2006 Aug;14(8):1285-92. PMID:16905102
Page seeded by OCA on Wed Nov 21 11:50:45 2007
Categories: Mus musculus | Protein complex | Bergamin, E. | Hubbard, S.R. | Wu, J. | Gp130 | Peptide complex | Ptyr | Socs3
