1pw6

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Image:1pw6.png

Template:STRUCTURE 1pw6

Contents

Low Micromolar Small Molecule Inhibitor of IL-2

Template:ABSTRACT PUBMED 14664558

Disease

Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680]

About this Structure

1PW6 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:14664558 doi:10.1021/ja0382617

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