Sandbox 4
From Proteopedia
The protein is associated with Pfam[1] entry PF06983 of 3-demethylubiquinone-9 3-methyltransferases.
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The potential substrate S-adenosyl-L-methionine has positive formal charge which fits the negative electrostatic potential in the potential catalytic area. The alternative substrate found by the structural homology methylglyoxal is not charged and thus less probable to attach to the potential catalytic area.
It seems more likely that Q8NX24 belongs to the Glyoxalase/bleomycin resistance protein/dioxygenase superfamily and functions as a demethylubiquinone-9 3-methyltransferase protein.
References
- ↑ Finn R, Griffiths-Jones S, Bateman A. (2003). Identifying protein domains with the Pfam database. Curr Protoc Bioinformatics. Chapter 2: Unit 2.5.
