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Sandbox28

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GLYCOGEN SYNTHASE KINASE 3 BETA

Glycogen Synthase Kinase 3 Beta has in the two opposite quadrants and alpha helices in the other two opposite quadrants. There are also two active sites that can be seen here:

1h8f, resolution 2.80Å ()

Ligands:

Activity:

Non-specific serine/threonine protein kinase, with EC number 2.7.11.1

Structural annotation:
Resources:	CATH : 1H8Fa02, 1H8Fa01, 1H8Fb02, 1H8Fb01 InterPro : Ipr011009, Ipr000719, Ipr008271, Ipr002290 Pfam : PF00069 SCOP : d1h8fa_, d1h8fb_ UniProt : P49841

Functional annotation:
Cellular component:	cytoplasm nucleus beta-catenin destruction complex
Biological process:	positive regulation of protein export from nucleus peptidyl-serine phosphorylation Wnt receptor signaling pathway through beta-catenin ER overload response Wnt receptor signaling pathway negative regulation of apoptosis protein amino acid phosphorylation intracellular signaling cascade glycogen metabolic process
Molecular function:	nucleotide binding ATP binding transferase activity p53 binding NF-kappaB binding kinase activity protein serine/threonine kinase activity protein kinase activity protein binding glycogen synthase kinase 3 activity

Evolutionary conservation:

Toggle Conservation Colors:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

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Sandbox28

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GLYCOGEN SYNTHASE KINASE 3 BETA

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