3cde
From Proteopedia
Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
Template:ABSTRACT PUBMED 18457949
About this Structure
3CDE is a 2 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072
Page seeded by OCA on Wed Mar 4 14:41:36 2009
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Han, Q. | Kissinger, C R. | Showalter, R E. | Zhao, Q. | Atp-binding | Host-virus interaction | Hydrolase | Metal-binding | Nucleotide-binding | Nucleotidyltransferase | Protein-ligand complex | Ribonucleoprotein | Rna replication | Rna-binding | Rna-directed rna polymerase | Transcription | Transcription regulation | Transferase | Viral nucleoprotein | Virion
