Triose Phosphate Isomerase

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'Triose Phosphate Isomerase

Image:TPI2.png

Template:STRUCTURE 1tim

Contents 1 Overview 2 Mechanism 2.1 Acid Base Catalysis 3 Structure & Function 4 Disease 4.1 Triose Phosphate Isomerase Deficiency 5 See Also 6 References

Overview

(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.

Mechanism

TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>

Acid Base Catalysis

Image:TPI mechanism.jpg

Diagram .<ref name= "web.virginia.edu" [1]

Structure & Function

Disease

Triose Phosphate Isomerase Deficiency

'Triose_Phosphate_Isomerase/Alpha_helices_and_beta_sheets/2'

See Also

References

 Triose Phosphate Isomerase [[2]]
Triose Phosphate Isomerase Deficiency [[3]]