2oar
From Proteopedia
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Mechanosensitive Channel of Large Conductance (MscL)
Overview
Mechanosensitive ion channels play a critical role in transducing physical, stresses at the cell membrane into an electrochemical response. The MscL, family of large-conductance mechanosensitive channels is widely, distributed among prokaryotes and may participate in the regulation of, osmotic pressure changes within the cell. In an effort to better, understand the structural basis for the function of these channels, the, structure of the MscL homolog from Mycobacterium tuberculosis was, determined by x-ray crystallography to 3.5 angstroms resolution. This, channel is organized as a homopentamer, with each subunit containing two, transmembrane alpha helices and a third cytoplasmic alpha helix. From the, extracellular side, a water-filled opening approximately 18 angstroms in, diameter leads into a pore lined with hydrophilic residues which narrows, at the cytoplasmic side to an occluded hydrophobic apex that may act as, the channel gate. This structure may serve as a model for other, mechanosensitive channels, as well as the broader class of pentameric, ligand-gated ion channels exemplified by the nicotinic acetylcholine, receptor.
About this Structure
2OAR is a Single protein structure of sequence from Mycobacterium tuberculosis with AU as ligand. This structure superseeds the now removed PDB entry 1MSL. Full crystallographic information is available from OCA.
Reference
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:9856938
Page seeded by OCA on Wed Nov 21 13:07:04 2007
