3g5e

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Image:3g5e.jpg

Template:STRUCTURE 3g5e

Human aldose reductase complexed with IDD 740 inhibitor

Template:ABSTRACT PUBMED 19250825

About this Structure

3G5E is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Van Zandt MC, Doan B, Sawicki DR, Sredy J, Podjarny AD. Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]ac etic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2006-8. Epub 2009 Feb 12. PMID:19250825 doi:10.1016/j.bmcl.2009.02.037

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