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Sandbox 70

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Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY.

About Topoisomerases

You may wonder do DNA get tangle or do they get stressed?Well the answer is yes but there a protein that relaxes and untangles DNA,it called Topoisomerases. Topoisomerases is a protein that untangle and relax DNA.

1a36, resolution 2.80Å ()

Activity:

DNA topoisomerase, with EC number 5.99.1.2

Structural annotation:
Resources:	CATH : 1A36A03, 1A36A02, 1A36A01, 1A36A04 InterPro : Ipr011010, Ipr009054, Ipr013500, Ipr013499, Ipr001631, Ipr013030, Ipr008336, Ipr014727, Ipr014711 Pfam : PF02919, PF01028 SCOP : d1a36a2, d1a36a1, d1a36a3 UniProt : P11387

Functional annotation:
Cellular component:	nucleolus perikaryon chromosome nucleoplasm cytoplasm nucleus
Biological process:	DNA unwinding during replication response to drug embryonic cleavage phosphorylation DNA topological change programmed cell death DNA replication
Molecular function:	DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity DNA binding chromatin binding protein binding isomerase activity DNA topoisomerase type I activity