2j4x
From Proteopedia
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STREPTOCOCCUS DYSGALACTIAE-DERIVED MITOGEN (SDM)
Overview
Bacterial superantigens are protein toxins with an ability to cause, serious diseases in humans by activating a large number of T cells., Streptococcus dysgalactiae-derived mitogen (SDM) is a novel superantigen, that is distinct from other known superantigens based on phylogenetic, analysis. The X-ray structure of SDM has been determined at 1.95 A, resolution. SDM shares the same characteristic fold with other, superantigens, but it shows a major structural difference due to the lack, of the alpha5 helix between the beta10 and beta11 strands. A bound zinc, ion was identified in the structure at the C-terminal domain of the, molecule. SDM appears to bind to the major histocompatibility complex, class II beta-chain through the zinc-binding site, as described by, mutagenesis data and ... [(full description)]
About this Structure
2J4X is a [Single protein] structure of sequence from [Streptococcus dysgalactiae] with ZN and GOL as [ligands]. Full crystallographic information is available from [OCA].
Reference
Crystal Structure of Streptococcus dysgalactiae-Derived Mitogen Reveals a Zinc-Binding Site and Alterations in TcR Binding., Saarinen S, Kato H, Uchiyama T, Miyoshi-Akiyama T, Papageorgiou AC, J Mol Biol. 2007 Nov 9;373(5):1089-97. Epub 2007 Aug 21. PMID:17900619
Page seeded by OCA on Mon Oct 29 23:05:25 2007
