2v9s

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models 2v9s, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

SECOND LRR DOMAIN OF HUMAN SLIT2

Overview

Slits are large multidomain leucine-rich repeat (LRR)-containing proteins, that provide crucial guidance cues in neuronal and vascular development., More recently, Slits have been implicated in heart morphogenesis, angiogenesis, and tumor metastasis. Slits are ligands for the Robo, (Roundabout) receptors, which belong to the Ig superfamily of, transmembrane signaling molecules. The Slit-Robo interaction is mediated, by the second LRR domain of Slit and the two N-terminal Ig domains of, Robo, but the molecular details of this interaction and how it induces, signaling remain unclear. Here we describe the crystal structures of the, second LRR domain of human Slit2 (Slit2 D2), the first two Ig domains of, its receptor Robo1 (Ig1-2), and the minimal complex between these proteins, (Slit2 ... [(full description)]

About this Structure

2V9S is a [Single protein] structure of sequence from [Homo sapiens] with GOL and PEG as [ligands]. Full crystallographic information is available from [OCA].

Reference

Structural insights into the Slit-Robo complex., Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA, Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14923-8. Epub 2007 Sep 11. PMID:17848514

Page seeded by OCA on Mon Oct 29 23:06:00 2007