2v7b
From Proteopedia
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CRYSTAL STRUCTURES OF A BENZOATE COA LIGASE FROM BURKHOLDERIA XENOVORANS LB400
Overview
Xenobiotic aromatic compounds represent one of the most significant, classes of environmental pollutants. A novel benzoate oxidation (box), pathway has been identified recently in Burkholderia xenovorans LB400, (referred to simply as LB400) that is capable of assimilating benzoate and, intimately tied to the degradation of polychlorinated biphenyls (PCBs)., The box pathway in LB400 is present in two paralogous copies (box(M) and, box(C)) and encodes eight enzymes with the first committed step catalyzed, by benzoate CoA ligase (BCL). As a first step towards delineating the, biochemical role of the box pathway in LB400, we have carried out, functional studies of the paralogous BCL enzymes (BCL(M) and BCL(C)) with, 20 different putative substrates. We have established a structural, rationale ... [(full description)]
About this Structure
2V7B is a [Single protein] structure of sequence from [Burkholderia xenovorans] with BEZ as [ligand]. Active as [[1]], with EC number [6.2.1.25]. Full crystallographic information is available from [OCA].
Reference
Biochemical and Structural Characterization of the Paralogous Benzoate CoA Ligases from Burkholderia xenovorans LB400: Defining the Entry Point into the Novel Benzoate Oxidation (box) Pathway., Bains J, Boulanger MJ, J Mol Biol. 2007 Aug 19;. PMID:17884091
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