159d
From Proteopedia
|
SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX
Overview
Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between, distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two, distamycin A molecules are bound side by side with dyad symmetry in an, antiparallel orientation in the expanded minor groove. The amides of each, drug molecule are hydrogen bonded to the minor groove base atoms of only, one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the, helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a, dinucleotide repeat.
About this Structure
159D is a Protein complex structure of sequences from [1] with DMY and MG as ligands. Full crystallographic information is available from OCA.
Reference
Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:7656035
Page seeded by OCA on Sat Nov 24 22:00:39 2007
Categories: Protein complex | Chen, X. | Ramakrishnan, B. | Rao, S.T. | Sundaralingam, M. | DMY | MG | B-dna | Complexed with drug | Double helix | Modified
