1m85

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Image:1m85.gif

1m85, resolution 2.00Å

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Structure of Proteus mirabilis catalase for the native form

Overview

A catalase from a peroxide resistant mutant of Proteus mirabilis binds, NADPH tightly. Interestingly, this enzyme can be stripped of NADPH without, loss of the catalatic activity. It is the only known non-mammalian, catalase able to bind NADPH. The structure without cofactor was solved by, molecular replacement using the structure of beef liver catalase as a, model. The structure was refined to an R-factor of 19.3% in the range 8 to, 2.2 A resolution. According to the sequence, a methionine sulphone was, positioned in the haem active site. This oxidized form of methionine is, particular to ... [(full description)]

About this Structure

1M85 is a [Protein single] structure of sequence from [Proteus mirabilis] with SO4, HEM and GOL as [ligands]. This structure superseeds the now removed PDB entries 2CAE and 1CAE.

Reference

Crystal structure of Proteus mirabilis PR catalase with and without bound NADPH., Gouet P, Jouve HM, Dideberg O, J Mol Biol. 1995 Jun 23;249(5):933-54. PMID:7791219

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