1r8o

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Image:1r8o.jpg

1r8o, resolution 1.83Å

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Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds

Overview

The crystallographic structure of a novel trypsin inhibitor (CTI) from, Copaifera langsdorffii is reported. The structure was solved by MIRAS, procedure and refined to a crystallographic residual of 17.3% (R(free) =, 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by, quick cryo-soaking approach. CTI is the first structure of a member of, Kunitz (STI) family formed by two noncovalently bound polypeptide chains, and only one disulfide bridge. A standard Kunitz-type inhibitor has a, single polypeptide chain and two disulfide bridges. Structural features, granting CTI high inhibitory activity are discussed.

About this Structure

1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830

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