2k9r

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Image:2k9r.png

Template:STRUCTURE 2k9r

Contents

Enhancing the activity of insulin by stereospecific unfolding

Template:ABSTRACT PUBMED 19321436

Disease

Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[176730]

About this Structure

2K9R is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem. 2009 May 22;284(21):14586-96. Epub 2009 Mar 25. PMID:19321436 doi:10.1074/jbc.M900085200

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