1rau
From Proteopedia
|
SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
Overview
A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has, been obtained by two-dimensional NMR spectroscopy and molecular dynamics., The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange, half-lives measured in days at 40 degrees C. The tetraplex is stabilized, by base stacking and by the hydrogen bonds in four G quartets and at least, one U quartet. This is the first indication of the existence of U-quartet, structures of which we are aware.
About this Structure
1RAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577
Page seeded by OCA on Sat Nov 24 22:27:11 2007
Categories: Protein complex | Cheong, C. | Moore, P.B. | Nmr | Rna | Tetraplex
