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2kfx

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Image:2kfx.jpg

Template:STRUCTURE 2kfx

Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7

Template:ABSTRACT PUBMED 19419198

About this Structure

2KFX is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hoffman RM, Sykes BD. Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C. Biochemistry. 2009 May 21. PMID:19419198 doi:10.1021/bi9001826
  • Li MX, Spyracopoulos L, Sykes BD. Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C. Biochemistry. 1999 Jun 29;38(26):8289-98. PMID:10387074 doi:10.1021/bi9901679
  • Wang X, Li MX, Sykes BD. Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil. J Biol Chem. 2002 Aug 23;277(34):31124-33. Epub 2002 Jun 11. PMID:12060657 doi:10.1074/jbc.M203896200

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