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1iy0
From Proteopedia
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Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus
Overview
FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in, concert with unfolding. The FtsH protein is divided into the N-terminal, transmembrane region and the larger C-terminal cytoplasmic region, which, consists of an ATPase domain and a protease domain. We have determined the, crystal structures of the Thermus thermophilus FtsH ATPase domain in the, nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the, domain with the extra preceding segment. Combined with the mapping of the, putative substrate binding region, these structures suggest that FtsH, internally forms a hexameric ring structure, in which ATP binding could, cause a conformational change to facilitate transport of substrates into, the protease domain through the central pore.
About this Structure
1IY0 is a Single protein structure of sequence from Thermus thermophilus with ANP as ligand. Full crystallographic information is available from OCA.
Reference
Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127
Page seeded by OCA on Sat Nov 24 22:45:27 2007
