1ndn
From Proteopedia
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MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4
Overview
The molecular structure of a nicked dodecamer DNA double helix, made of a, ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG), oligonucleotides, has been determined by x-ray diffraction analysis at 3 A, resolution. The molecule adopts a B-DNA conformation, not unlike those, found in intact dodecamer DNA molecules crystallized in a somewhat, different crystal lattice, despite a gap due to the absence of a phosphate, group in the molecule. The helix has a distinct narrow minor groove near, the center of the molecule at the AAAA region. This suggests that the, internal stabilizing forces due to base stacking and hydrogen-bonding, interactions are sufficient to overcome the loss of connectivity, associated with the disruption of the covalent backbone of DNA.
About this Structure
1NDN is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:2320572
Page seeded by OCA on Sat Nov 24 22:58:16 2007
