1s58
From Proteopedia
|
The structure of B19 parvovirus capsid
Overview
Human parvovirus B19 is the only parvovirus known to be a human pathogen., The structure of recombinant B19-like particles has been determined to, approximately 3.5-A resolution by x-ray crystallography and, to our, knowledge, represents the first near-atomic structure of an Erythrovirus., The polypeptide fold of the major capsid protein VP2 is a "jelly roll", with a beta-barrel motif similar to that found in many icosahedral, viruses. The large loops connecting the strands of the beta-barrel form, surface features that differentiate B19 from other parvoviruses. Although, B19 VP2 has only 26% sequence identity to VP3 of adeno-associated virus, 72% of the C(alpha) atoms can be aligned structurally with a rms deviation, of 1.8 A. Both viruses require an integrin as a coreceptor, and conserved, surface features suggest a common receptor-binding region.
About this Structure
1S58 is a Protein complex structure of sequences from Human parvovirus b19. Full crystallographic information is available from OCA.
Reference
The structure of human parvovirus B19., Kaufmann B, Simpson AA, Rossmann MG, Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11628-33. Epub 2004 Aug 2. PMID:15289612
Page seeded by OCA on Sat Nov 24 23:55:28 2007
