1o0k
From Proteopedia
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Structure of the First Parallel DNA Quadruplex-drug Complex
Overview
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
About this Structure
1O0K is a Protein complex structure of sequences from [1] with DM1 and NA as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225
Page seeded by OCA on Sun Nov 25 00:09:02 2007
