3g04

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Image:3g04.jpg


PDB ID 3g04

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3g04, resolution 2.55Å ()
Ligands: ,
Gene: TSHR (Homo sapiens)
Related: 1xwd
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

Template:ABSTRACT PUBMED 17542669

Disease

Known disease associated with this structure: Hyperthyroidism, familial gestational OMIM:[603372], Hyperthyroidism, nonautoimmune OMIM:[603372], Hypothyroidism, congenital, nongoitrous, 1 275200 OMIM:[603372], Thyroid adenoma, hyperfunctioning, somatic OMIM:[603372], Thyroid carcinoma with thyrotoxicosis OMIM:[603372]

About this Structure

3G04 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid. 2007 May;17(5):395-410. PMID:17542669 doi:10.1089/thy.2007.0034
  • Sanders J, Evans M, Premawardhana LD, Depraetere H, Jeffreys J, Richards T, Furmaniak J, Rees Smith B. Human monoclonal thyroid stimulating autoantibody. Lancet. 2003 Jul 12;362(9378):126-8. PMID:12867115
  • Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Kiddie A, Brereton K, Premawardhana LD, Chirgadze DY, Nunez Miguel R, Blundell TL, Furmaniak J, Rees Smith B. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid. 2004 Aug;14(8):560-70. PMID:15320966 doi:10.1089/1050725041692918
  • Nunez Miguel R, Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Blundell TL, Rees Smith B, Furmaniak J. Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. Thyroid. 2004 Dec;14(12):991-1011. PMID:15650352 doi:10.1089/thy.2004.14.991
  • Sanders J, Bolton J, Sanders P, Jeffreys J, Nakatake N, Richards T, Evans M, Kiddie A, Summerhayes S, Roberts E, Miguel RN, Furmaniak J, Smith BR. Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. Thyroid. 2006 Dec;16(12):1195-206. PMID:17199429 doi:10.1089/thy.2006.16.1195
  • Sanders J, Miguel RN, Bolton J, Bhardwaja A, Sanders P, Nakatake N, Evans M, Furmaniak J, Smith BR. Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody. Thyroid. 2007 Aug;17(8):699-706. PMID:17725428 doi:10.1089/thy.2007.0041
  • Nunez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. J Mol Endocrinol. 2008 Sep;41(3):145-64. Epub 2008 Jul 7. PMID:18606720 doi:10.1677/JME-08-0040

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