Jonathan O'Donnell sandbox 1
From Proteopedia
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| 3d06, resolution 1.20Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | TP53 (Homo sapiens) | ||||||||
| Related: | 3d05, 3d07, 3d08, 3d09, 3d0a | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Human p53 core domain with hot spot mutation R249S (I)
Template:ABSTRACT PUBMED 18996393
Disease
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Histiocytoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Multiple malignancy syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170], Thyroid carcinoma OMIM:[191170]
About this Structure
3D06 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063
Page seeded by OCA on Wed Jan 21 10:44:12 2009
Categories: Homo sapiens | Frolow, F. | Rozenberg, H. | Shakked, Z. | Shimon, L J.W. | Suad, O. | Acetylation | Activator | Alternative splicing | Anti-oncogene | Apoptosis | Cell cycle | Covalent protein-rna linkage | Cytoplasm | Disease mutation | Dna-binding | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Loop-sheet-helix motif | Metal-binding | Methylation | Mutant protein | Nucleus | P53 | Phosphoprotein | Polymorphism | Transcription | Transcription regulation | Ubl conjugation | Zinc
