1gw5

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spinqualitylabelsall models 1gw5, resolution 2.59Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

AP2 CLATHRIN ADAPTOR CORE

Overview

AP2 is the best-characterized member of the family of heterotetrameric, clathrin adaptor complexes that play pivotal roles in many vesicle, trafficking pathways within the cell. AP2 functions in clathrin-mediated, endocytosis, the process whereby cargo enters the endosomal system from, the plasma membrane. We describe the structure of the 200 kDa AP2 "core", (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the, polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A, resolution. Two potential polyphosphatidylinositide binding sites are, observed, one on alpha and one on mu2. The binding site for Yxxphi, endocytic motifs is buried, indicating that a conformational change, probably triggered by phosphorylation in the disordered mu2 linker, is, necessary to allow ... [(full description)]

About this Structure

1GW5 is a [Protein complex] structure of sequences from [Homo sapiens], [Mus musculus] and [Rattus norvegicus] with IHP as [ligand]. The following page contains interesting information on the relation of 1GW5 with [Clathrin]. Structure known Active Site: IHP. Full crystallographic information is available from [OCA].

Reference

Molecular architecture and functional model of the endocytic AP2 complex., Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ, Cell. 2002 May 17;109(4):523-35. PMID:12086608

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