Sandbox 81

From Proteopedia

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Alpha Lactalbumin

α-lactalbumin is a small globular protein which is stabilized by four disulfide bonds with two structural domains. One domain is rich in α-helices, the other is rich in β-sheets and has a calcium binding site. ^[1] α-lactalbumin is a major protein in all kinds of milk studied so far. ^[2] α- lactalbumin contributes to cell lytic activity, cell growth inhibition, and apoptosis but most importantly, it interacts with UDP-galactosyltransferase ^[2] to form lactose synthetase via the following reaction:

UDP-galactose + glucose -+ lactose + UDP ^[3]

spinqualitylabelsall models PDB ID 1a4v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1a4v, resolution 1.80Å ()
Ligands:
Activity:	Lactose synthase, with EC number 2.4.1.22
Structural annotation: Resources: CATH : 1A4V000 InterPro : Ipr000545, Ipr001916 Pfam : PF00062 SCOP : d1a4v__ UniProt : P00709
Functional annotation: Cellular component: extracellular region extracellular space Biological process: signal transduction lactose biosynthetic process cell-cell signaling defense response to bacterium induction of apoptosis Molecular function: lactose synthase activity calcium ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

: with alpha helices shown in pink rockets, and beta sheets shown in yellow planks.

: with nonpolar side chains in gray, polar side chains in purple, and associated water molecules in red.

References

1. ↑ Hendrix TM, Griko Y, Privalov P. 1996. Energetics of structural domains in α-lactalbumin. Protein Science. 5923-5931.
2. ↑ ^{2.0 2.1} Vilotte JL. Alpha-lactalbumin: Gene Structure and Expression. <http://mammary.nih.gov/Reviews/gene_expression/Vilotte001/index.html>.
3. ↑ Fitzgerald DK, Brodbeck URS, Kiyosawa I, Mawal R, Colvin B, Ebner KE. 1970. α-lactalbumin and the Lactose Synthetase Reaction. The Journal of Biological Chemistry. 245(8): 2103-2108.