3eig

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Image:3eig.png

Template:STRUCTURE 3eig

Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase

Template:ABSTRACT PUBMED 19478082

About this Structure

3EIG is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. J Biol Chem. 2009 Jul 24;284(30):20079-89. Epub 2009 May 28. PMID:19478082 doi:10.1074/jbc.M109.018010

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