3hr1

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Image:3hr1.png

Template:STRUCTURE 3hr1

Discovery of novel inhibitors of PDE10A

Template:ABSTRACT PUBMED 19630403

About this Structure

3HR1 is a 1 chain structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). J Med Chem. 2009 Jul 24. PMID:19630403 doi:10.1021/jm900521k

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