1qo0
From Proteopedia
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AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.
Overview
Inducible expression of the aliphatic amidase operon in Pseudomonas, aeruginosa is controlled by an antitermination mechanism which allows, production of the full-length transcript only in the presence of, small-molecule inducers, such as acetamide. Ligand-regulated, antitermination is provided by AmiC, the ligand-sensitive negative, regulator, and AmiR, the RNA-binding positive regulator. Under, non-inducing or repressing growth conditions, AmiC and AmiR form a complex, in which the activity of AmiR is silenced. The crystal structure of the, AmiC-AmiR complex identifies AmiR as a new and highly unusual member of, the response-regulator family of bacterial signal transduction proteins, regulated by sequestration rather than phosphorylation. Comparison with, the structure of free AmiC ... [(full description)]
About this Structure
1QO0 is a [Protein complex] structure of sequences from [Pseudomonas aeruginosa] with BMD as [ligand]. Structure known Active Sites: LGA and LGB. Full crystallographic information is available from [OCA].
Reference
Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex., O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH, EMBO J. 1999 Oct 1;18(19):5175-86. PMID:10508151
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