4nph

Structural highlights

Function

SCTN2_SALTY ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:24722491). Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity). Required for type III secretion apparatus (T3SA) formation, secretion of a subset of SPI-2 effectors and virulence (PubMed:24722491, PubMed:25035427). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (Probable). Releases the effector protein SseB from the T3SS-2 specific chaperone SsaE in an ATP-dependent manner (PubMed:24722491).[UniProtKB:P0A1B9]^{[1] [2] [3] [4]}

References

1. ↑ Yoshida Y, Miki T, Ono S, Haneda T, Ito M, Okada N. Functional characterization of the type III secretion ATPase SsaN encoded by Salmonella pathogenicity island 2. PLoS One. 2014 Apr 10;9(4):e94347. doi: 10.1371/journal.pone.0094347. eCollection , 2014. PMID:24722491 doi:http://dx.doi.org/10.1371/journal.pone.0094347
2. ↑ Allison SE, Tuinema BR, Everson ES, Sugiman-Marangos S, Zhang K, Junop MS, Coombes BK. Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo. J Biol Chem. 2014 Aug 22;289(34):23734-44. doi: 10.1074/jbc.M114.578476. Epub , 2014 Jul 17. PMID:25035427 doi:http://dx.doi.org/10.1074/jbc.M114.578476
3. ↑ Yoshida Y, Miki T, Ono S, Haneda T, Ito M, Okada N. Functional characterization of the type III secretion ATPase SsaN encoded by Salmonella pathogenicity island 2. PLoS One. 2014 Apr 10;9(4):e94347. doi: 10.1371/journal.pone.0094347. eCollection , 2014. PMID:24722491 doi:http://dx.doi.org/10.1371/journal.pone.0094347
4. ↑ Allison SE, Tuinema BR, Everson ES, Sugiman-Marangos S, Zhang K, Junop MS, Coombes BK. Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo. J Biol Chem. 2014 Aug 22;289(34):23734-44. doi: 10.1074/jbc.M114.578476. Epub , 2014 Jul 17. PMID:25035427 doi:http://dx.doi.org/10.1074/jbc.M114.578476