Structural highlights
Disease
VP37A_HUMAN Autosomal recessive spastic paraplegia type 53. The disease is caused by variants affecting the gene represented in this entry.
Function
VP37A_HUMAN Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.[1]
See Also
References
- ↑ Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H. The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell. 2004 Sep;15(9):4337-46. PMID:15240819 doi:10.1091/mbc.e04-03-0250
